SIMBASTATIN+VITAMIN D3 IN MIGRAINE

Simvastatin, Vitamin D3 Combo Effective in Episodic Migraine

Simvastatin, Vitamin D3 Combo Effective in Episodic Migraine

The combination of simvastatin and vitamin D3 seems effective for prevention of headache in adults with episodic migraine, according to a study published in the Annals of Neurology.

Un that work examined the efficacy and tolerability of simvastatin plus vitamin D for migraine prevention.

Fifty-seven adults with episodic migraine were randomized to simvastatin 20 mg tablets twice daily plus vitamin D3 1,000 IU capsules twice daily or matching placebo tablets and capsules during a 24-week intervention period.

The researchers found that, compared with placebo, participants using simvastatin plus vitamin D3 demonstrated a greater decrease in number of migraine days from the baseline period to intervention weeks one to 12  and to intervention weeks 13 to 24. In the active treatment group, 25 and 29% of patients experienced a 50% reduction in the number of migraine days at 12 and 24 weeks post randomization, respectively. Only 3% of patients experienced such reduction in the placebo group.

The treatment and placebo groups reported similar adverse events.

Given statins ability to repair endothelial dysfunction, this economical approach may also reduce the increased risk for vascular diseases among migraineurs.

Beuttner C et al. Ann Neurol. 2015; doi:10.1002/ana.24534. 

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